Issue 27, 2017

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Abstract

Phosphate-based bioactive glasses (PBGs) dissolve harmlessly in the body with a dissolution rate which depends sensitively on composition. This makes them proposed vectors for e.g. drug delivery, or other applications where an active component needs to be delivered at a therapeutically appropriate rate. Molecular dynamics (MD) simulations provide atomic-level structural information about PBG compositions. We review recent work to show that MD is an excellent tool to unravel the connections between the PBG glass composition, its atomic structure, and its dissolution rate, which can help to optimise PBGs for specific medical applications.

Graphical abstract: Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

Article information

Article type
Review Article
Submitted
06 May 2017
Accepted
15 Jun 2017
First published
15 Jun 2017

J. Mater. Chem. B, 2017,5, 5297-5306

Structures and properties of phosphate-based bioactive glasses from computer simulation: a review

J. K. Christie, R. I. Ainsworth, S. E. R. Hernandez and N. H. de Leeuw, J. Mater. Chem. B, 2017, 5, 5297 DOI: 10.1039/C7TB01236E

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