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Issue 22, 2017
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A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

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Abstract

We report the synthesis of a near-infrared (NIR) fluorescent pH probe with a remarkable Stokes shift (∼135 nm) based on a tricarbocyanine (Cy-PIP). The fluorescent molecule was anchored to SiO2 nanoparticles (Cy-PIP@SiO2) and is capable of monitoring pH changes within the physiological range (pH 6–8). The Cy-PIP@SiO2 nanoparticles were successfully internalized by HeLa cells as shown by fluorescence confocal microscopy, while flow cytometry revealed pH fluctuations during the endocytic pathway.

Graphical abstract: A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

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Supplementary files

Article information


Submitted
06 Mar 2017
Accepted
16 May 2017
First published
16 May 2017

J. Mater. Chem. B, 2017,5, 4031-4034
Article type
Communication

A silica supported tricarbocyanine based pH nanosensor with a large Stokes shift and a near infrared fluorescence response: performance in vitro and in live cells

Y. Toum Terrones, F. Coluccio Leskow, A. V. Bordoni, S. L. Acebedo, C. C. Spagnuolo and A. Wolosiuk, J. Mater. Chem. B, 2017, 5, 4031
DOI: 10.1039/C7TB00622E

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