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Issue 5, 2017
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A highly sensitive and reusable electrochemical mercury biosensor based on tunable vertical single-walled carbon nanotubes and a target recycling strategy

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Abstract

In this work, a novel electrochemical Hg2+ biosensor with high sensitivity and excellent reusability was presented. The sensor was based on tunable vertical single-walled carbon nanotubes (v-SWCNTs) and a target recycling strategy. A facile and scalable approach involving the conformational regulation of self-assembled monolayers was established for the fabrication of v-SWCNTs with tailored orientation and homogeneity. The obtained v-SWCNTs exhibited superior properties including a large specific area, high electrical conductivity, and excellent substrate binding strength, opening up a wide horizon for advanced electrochemical applications. Meanwhile, an efficient Hg2+ recycling strategy was designed using exonuclease III. In this strategy, a trace amount of Hg2+ triggered consecutive nicking reactions, and numerous report probes were released to bind with v-SWCNTs through π–π interactions. Based on the innovative design, an ultralow detection limit of 3 fM (S/N = 3), a wide linear range from 10 fM to 1 μM, high selectivity, and good reliability were achieved for a Hg2+ assay in water and serum samples using the prepared biosensor. Besides, due to the reversibility of π–π interactions, the stable v-SWCNT interface was regenerated for 50 consecutive measurements without obvious signal loss, making it a promising candidate for routine and efficient Hg2+ monitoring.

Graphical abstract: A highly sensitive and reusable electrochemical mercury biosensor based on tunable vertical single-walled carbon nanotubes and a target recycling strategy

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Publication details

The article was received on 12 Oct 2016, accepted on 23 Dec 2016 and first published on 23 Dec 2016


Article type: Paper
DOI: 10.1039/C6TB02658C
J. Mater. Chem. B, 2017,5, 1073-1080

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    A highly sensitive and reusable electrochemical mercury biosensor based on tunable vertical single-walled carbon nanotubes and a target recycling strategy

    L. Shi, Y. Wang, Z. Chu, Y. Yin, D. Jiang, J. Luo, S. Ding and W. Jin, J. Mater. Chem. B, 2017, 5, 1073
    DOI: 10.1039/C6TB02658C

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