Issue 3, 2017

Bimetallic catalysis for C–C and C–X coupling reactions


Bimetallic catalysis represents an alternative paradigm for coupling chemistry that complements the more traditional single-site catalysis approach. In this perspective, recent advances in bimetallic systems for catalytic C–C and C–X coupling reactions are reviewed. Behavior which complements that of established single-site catalysts is highlighted. Two major reaction classes are covered. First, generation of catalytic amounts of organometallic species of e.g. Cu, Au, or Ni capable of transmetallation to a Pd co-catalyst (or other traditional cross-coupling catalyst) has allowed important new C–C coupling technologies to emerge. Second, catalytic transformations involving binuclear bond-breaking and/or bond-forming steps, in some cases involving metal–metal bonds, represent a frontier area for C–C and C–X coupling processes.

Graphical abstract: Bimetallic catalysis for C–C and C–X coupling reactions

Article information

Article type
19 Dec 2016
14 Jan 2017
First published
16 Jan 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 1705-1718

Bimetallic catalysis for C–C and C–X coupling reactions

D. R. Pye and N. P. Mankad, Chem. Sci., 2017, 8, 1705 DOI: 10.1039/C6SC05556G

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