Jump to main content
Jump to site search

Issue 4, 2017
Previous Article Next Article

Copper(I)-catalyzed sulfonylative Suzuki–Miyaura cross-coupling

Author affiliations


Using a simple copper(I) catalyst has allowed a high yielding sulfonylative-Suzuki–Miyaura cross-coupling reaction to be developed. The process provides a single step route to diaryl sulfones from the direct combination of aryl boronic acids, sulfur dioxide and aryl iodides, and represents the first sulfonylative variant of a classic cross-coupling reaction. Sulfur dioxide is delivered from the surrogate reagent, DABSO. Variation of the reaction conditions allowed interruption of the sulfonylative-Suzuki coupling, resulting in the formation of a presumed Cu–sulfinate intermediate. These sulfinates could be trapped as their sodium salts and treated with electrophiles to allow access to arylalkyl sulfones, β-hydroxyl sulfones, sulfonamides and sulfonyl fluorides.

Graphical abstract: Copper(i)-catalyzed sulfonylative Suzuki–Miyaura cross-coupling

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Dec 2016, accepted on 16 Feb 2017 and first published on 28 Feb 2017

Article type: Edge Article
DOI: 10.1039/C6SC05483H
Citation: Chem. Sci., 2017,8, 3249-3253
  • Open access: Creative Commons BY license
  •   Request permissions

    Copper(I)-catalyzed sulfonylative Suzuki–Miyaura cross-coupling

    Y. Chen and M. C. Willis, Chem. Sci., 2017, 8, 3249
    DOI: 10.1039/C6SC05483H

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author