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Issue 3, 2017
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AIE-active theranostic system: selective staining and killing of cancer cells

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Abstract

Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.

Graphical abstract: AIE-active theranostic system: selective staining and killing of cancer cells

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Supplementary files

Article information


Submitted
09 Nov 2016
Accepted
13 Dec 2016
First published
13 Dec 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2017,8, 1822-1830
Article type
Edge Article

AIE-active theranostic system: selective staining and killing of cancer cells

C. Gui, E. Zhao, R. T. K. Kwok, A. C. S. Leung, J. W. Y. Lam, M. Jiang, H. Deng, Y. Cai, W. Zhang, H. Su and B. Z. Tang, Chem. Sci., 2017, 8, 1822
DOI: 10.1039/C6SC04947H

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