Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions
Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other fundamental selectivity aspects facing the synthetic chemist. This perspective examines the progress that has been made in this area thus far using non-covalent interactions in conjunction with transition metal catalysis as well as in the context of purely organic catalysts. We hope this will highlight the great potential in this approach for designing selective catalytic reactions.
- This article is part of the themed collections: 1st International Conference on Noncovalent Interactions, Celebrating our 2019 Prize and Award winners, Most popular Chemical Science Review articles 2017-2018 and Most downloaded articles of 2017: Energy and Catalysis