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Double-stranded DNA-scaffolded fluorescent probes were developed for fluorescence imaging of molecules on cell surfaces. The probes contain double-stranded DNA of any desired length as a backbone which non-covalently or covalently conjugates with fluorescent dyes. The probes can be lab-made easily at low cost and stored for a very long time.

Graphical abstract: Double-stranded DNA-scaffolded fluorescent probes for fluorescence imaging of cell-surface molecules

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