Issue 72, 2017

K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols

Abstract

Convenient, practical and economical phosphorylation of thiols has been achieved via halogen- and metal-free K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites, dimethyl phenylphosphonite, or methyl diphenylphosphinite with thiophenols using air as the oxidant at room temperature. This transformation provides a straightforward route to the construction of phosphorus–sulfur bonds with wide functional group compatibility, which affords phosphorothioates in up to 94% yield.

Graphical abstract: K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols

Supplementary files

Article information

Article type
Paper
Submitted
16 Aug 2017
Accepted
18 Sep 2017
First published
25 Sep 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 45416-45419

K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols

C. Wen, Q. Chen, Y. Huang, X. Wang, X. Yan, J. Zeng, Y. Huo and K. Zhang, RSC Adv., 2017, 7, 45416 DOI: 10.1039/C7RA09057A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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