Issue 79, 2017, Issue in Progress

Collagen modified with epoxidized safrole for improving antibacterial activity

Abstract

An epoxidized safrole, 5-(oxiran-2-ylmethyl)-benzo[d][1,3]dioxole (OYBD), was synthesized and employed to modify collagen for improving its antibacterial activity. The interaction between collagen and OYBD, and the structure/properties of the modified collagen were investigated in detail. The results indicated that the OYBD-modified collagen showed a higher de-nature temperature (Td, 90.2 °C), improved hydrophobic properties (contact angle from 84.2° to 89.1°) and enhanced tensile strength (6.2–11.0%) without destroying its triple helix structure. From observation of scanning electron microscopy (SEM), a higher density of intertwining morphology and a more stable network structure were observed, which was consistent with improved tensile strength and reduced breaking extension stress. The antibacterial test and LIVE/DEAD Baclight bacterial viability assay illustrated that the modified collagen exhibited excellent antibacterial activity to both Gram-negative and Gram-positive bacteria. Furthermore, the OYBD-modified collagen still exhibited cytocompatibility, supporting human fibroblast proliferation, which holds a great potential for developing antibacterial collagen-based biomaterials.

Graphical abstract: Collagen modified with epoxidized safrole for improving antibacterial activity

Article information

Article type
Paper
Submitted
27 Jul 2017
Accepted
21 Oct 2017
First published
27 Oct 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 50300-50306

Collagen modified with epoxidized safrole for improving antibacterial activity

Z. Xu, J. Chang, P. Zhang, X. Guan, Y. Chen and H. Fan, RSC Adv., 2017, 7, 50300 DOI: 10.1039/C7RA08319J

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