Synthesis and characterization of a ZnMn2O4 nanostructure as a chemical nanosensor: a facile and new approach for colorimetric determination of omeprazole and lansoprazole drugs

Abstract

We have developed a facile method for preparation of ZnMn₂O₄ nanostructures via an auto-combustion method using various fuels: urea, glycine and L-alanine. The type of fuel and pH of the combustion media have a significant effect on the combustion products. Glycine fuel generated spinel ZnMn₂O₄ on combustion, and calcination of the sample produced pure spinel ZnMn₂O₄ nanoparticles with an average crystallite size of 19 nm. Whereas, other fuels generated multiphase compounds on combustion. The products were elucidated by means of XRD, FE-SEM, EDS, TEM, FT-IR, and UV-Vis diffuse reflectance spectra. The as-fabricated product was applied to construct a novel chemical nanosensor for the determination of omeprazole and lansoprazole drugs. Different factors influencing the colorimetric determination of the drugs were examined such as contact time, temperature, initial drug concentration, and ZnMn₂O₄ dose. The proposed chemical nanosensor revealed high sensitivity, low detection limit, and a relatively wide linear range (0.80–8.0 and 0.80–8.8 μg mL⁻¹ at λ_max 454 nm for omeprazole and lansoprazole, respectively).