Issue 63, 2017

Cs2CO3-promoted cross-dehydrogenative coupling of thiophenols with active methylene compounds

Abstract

A convenient and efficient α-sulfenylation of carbonyl compounds has been achieved via the halogen-free Cs2CO3-promoted cross-dehydrogenative coupling (CDC) of thiophenols with active methylene compounds using air as the oxidant under mild conditions. This transformation provides a straightforward route to the construction of carbon–sulfur bonds with wide functional group compatibility, which produces α-sulfenylated carbonyl compounds in up to 95% yield.

Graphical abstract: Cs2CO3-promoted cross-dehydrogenative coupling of thiophenols with active methylene compounds

Supplementary files

Article information

Article type
Paper
Submitted
20 Jun 2017
Accepted
08 Aug 2017
First published
15 Aug 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 39758-39761

Cs2CO3-promoted cross-dehydrogenative coupling of thiophenols with active methylene compounds

Q. Chen, X. Wang, C. Wen, Y. Huang, X. Yan and J. Zeng, RSC Adv., 2017, 7, 39758 DOI: 10.1039/C7RA06904A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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