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Issue 64, 2017
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Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

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Abstract

Amyloid β (Aβ) induced toxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The activities of ginsenosides against AD are widely reported, however, a systematic in vivo study comparing the effects of different ginsenosides on Aβ induced toxicity and cognitive impairment has not been described. In addition, the correlation between molecular structures and their anti-Aβ activities remains uncovered. In the present study, the in vivo anti-Aβ effects of 17 ginsenosides were explored using three transgenic Caenorhabditis elegans (C. elegans) models that exhibits pathological behaviors associated with Aβ. We found that (1) ginsenoside Rc, Rd, 20(S)-Rg3, Compound K (CK) and Rg1 could significantly reduce Aβ deposits, (2) ginsenoside Rc, Rd, CK, Rk3 and Rg1 inhibit Aβ induced paralysis, and (3) ginsenosides 20(S)-Rg3, CK and Rk3 prevented Aβ induced defects in associative learning capacity and showed antioxidative activity both in vitro and in vivo. The structure–activity relationships of 17 ginsenosides were investigated by comparing their anti-Aβ effects in C. elegans models. Results showed that the protopanaxadiol-type has higher activities than the protopanaxatriol-type or oleanane-type; the anti-Aβ effects of ginsenosides are inversely related to the sugar numbers. The results of the present study gain insight into the in vivo protective effects of ginsenosides against Aβ induced toxicity, and provide useful information for the clinical use of ginsenosides.

Graphical abstract: Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

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Supplementary files

Article information


Submitted
21 May 2017
Accepted
18 Jul 2017
First published
16 Aug 2017

This article is Open Access

RSC Adv., 2017,7, 40095-40104
Article type
Paper

Evaluation of structure–activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

M. Zhang, F. Qian, Q. Liu, C. Qian, P. M. Thu, Y. Wang, Z. Zheng, H. Yang, P. Li and X. Xu, RSC Adv., 2017, 7, 40095
DOI: 10.1039/C7RA05717B

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