Jump to main content
Jump to site search

Issue 64, 2017
Previous Article Next Article

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Author affiliations

Abstract

Tau reduction is a favorable strategy for Alzheimer's disease (AD) treatment. In this work, we designed and synthesized a hydrophobic tag conjugated peptide (HyT-Tau-CPP) to selectively promote the degradation of Tau. HyT-Tau-CPP could potently lower the Tau level in a concentration- and time-dependent manner. Furthermore, HyT-Tau-CPP could also reduce the level of Tau in the brain of AD mouse models. Therefore, Tau reduction by HyT-Tau-CPP may become a potential therapeutic strategy in the treatment for AD.

Graphical abstract: Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

Back to tab navigation

Supplementary files

Article information


Submitted
11 May 2017
Accepted
04 Aug 2017
First published
18 Aug 2017

This article is Open Access

RSC Adv., 2017,7, 40362-40366
Article type
Paper

Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau

N. Gao, T. Chu, Q. Li, Y. Lim, T. Qiu, M. Ma, Z. Hu, X. Yang, Y. Chen, Y. Zhao and Y. Li, RSC Adv., 2017, 7, 40362
DOI: 10.1039/C7RA05347A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements