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Issue 28, 2017
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Protein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract

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Abstract

Non-invasive imaging modalities such as computed tomography are often used for diagnosis and assessment of gastrointestinal (GI) disease status over the long-term. The physiology of the GI tract can be assessed with contrast agents. Here, we present common protein (bovine serum albumin, BSA) stabilized bismuth sulfide nanoparticles with robust X-ray attenuation. Under the optimal conditions, this agent can outline the anatomy of the mouse GI tract on 3D computed tomography imaging, with the real-time and non-invasive visualization of nanoparticle distribution and the GI tract. Moreover, the investigation on long-term toxicity and biodistribution of these nanoparticles after oral administration indicate their overall safety. This is a promising agent for GI visualization and disease diagnosis.

Graphical abstract: Protein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract

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Supplementary files

Article information


Submitted
06 Feb 2017
Accepted
08 Mar 2017
First published
21 Mar 2017

This article is Open Access

RSC Adv., 2017,7, 17505-17513
Article type
Paper

Protein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract

Y. Zu, Y. Yong, X. Zhang, J. Yu, X. Dong, W. Yin, L. Yan, F. Zhao, Z. Gu and Y. Zhao, RSC Adv., 2017, 7, 17505
DOI: 10.1039/C7RA01526G

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    [Original citation] - Published by The Royal Society of Chemistry.

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