Issue 34, 2017, Issue in Progress

Metformin as a versatile ligand for recyclable palladium-catalyzed cross-coupling reactions in neat water

Abstract

We present the high catalytic activity of an in situ generated palladium(II)/metformin complex in neat water for the Suzuki–Miyaura and Sonogashira cross-coupling reactions. These reactions were performed in pure water without any co-solvent or mass transfer agent. The palladium(II)/metformin complex gave excellent to good yields for the Suzuki–Miyaura coupling reaction and catalyzed with a certain specificity to the aryl iodide coupling in the Sonogashira reaction. The methodology showcases a recyclability up to four catalytic runs for the Suzuki–Miyaura cross-coupling reaction, performed with only 0.5 mol% palladium loading.

Graphical abstract: Metformin as a versatile ligand for recyclable palladium-catalyzed cross-coupling reactions in neat water

Supplementary files

Article information

Article type
Paper
Submitted
26 Jan 2017
Accepted
04 Apr 2017
First published
12 Apr 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 21036-21044

Metformin as a versatile ligand for recyclable palladium-catalyzed cross-coupling reactions in neat water

S. Fortun, P. Beauclair and A. R. Schmitzer, RSC Adv., 2017, 7, 21036 DOI: 10.1039/C7RA01197K

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