Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum

Xinhui Tian; Xin Guo; Zhiguo Zhuo; Rentao Zeng; Xin Fang; Xike Xu; Huiliang Li; Yunheng Shen; Weidong Zhang

doi:10.1039/C7RA01143A

Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum†

Xinhui Tian,

‡^a Xin Guo,‡^a Zhiguo Zhuo,^b Rentao Zeng,^b Xin Fang,^b Xike Xu,^b Huiliang Li,^b Yunheng Shen^b and Weidong Zhang*^abc

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* Corresponding authors

^a Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China
E-mail: wdzhangy@hotmail.com
Web: http://www.shutcm.edu.cn/

^b Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China

^c Innovative Research Center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 201204, P. R. China

Abstract

A phytochemical investigation on the branches and leaves of Illicium burmanicum led to the isolation of two unique allo-thujane-phenylpropane and lavandulane-phenylpropane hetero-adducts (1 and 2), two new prenylated phenylpropanoids (3 and 4), and one new neolignan (5). Their structures were established by comprehensive NMR and CD spectroscopic analysis. Burmaniols A (1) and B (2) showed appreciable cytotoxicity against A549 and HCT116 cells with IC₅₀ values of 6.40–7.76 μM.

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DOI: https://doi.org/10.1039/C7RA01143A
Article type: Paper
Submitted: 25 Jan 2017
Accepted: 06 Feb 2017
First published: 09 Feb 2017
This article is Open Access

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RSC Adv., 2017,7, 10849-10854

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Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum

X. Tian, X. Guo, Z. Zhuo, R. Zeng, X. Fang, X. Xu, H. Li, Y. Shen and W. Zhang, RSC Adv., 2017, 7, 10849 DOI: 10.1039/C7RA01143A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum†

Abstract

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Prenylated phenylpropanoids with unprecedented skeletons from Illicium burmanicum

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