Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via CC/C(sp3)–N bond cleavage of enones and primary amines†
Abstract
A one-pot acid-catalyzed tandem reaction has been developed without any metallic reagents or extra oxidants. This reaction involves a CC bond cleavage of enones via a “masked” reverse Aldol reaction, and C(sp3)–N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group tolerance.