Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C![[double bond, length as m-dash]](https://www.rsc.org/images/entities/char_e001.gif)
C/C(sp3)–N bond cleavage of enones and primary amines†
Heng-Shan
Wang, 
a
Ying-Ming
Pan
*a
a
Ying-Ming
Pan
*a
Abstract
A one-pot acid-catalyzed tandem reaction has been developed without any metallic reagents or extra oxidants. This reaction involves a CC bond cleavage of enones via a “masked” reverse Aldol reaction, and C(sp3)–N bond cleavage of primary amines to provide nitrogen sources for the assembly of pyridine derivatives in high yields with excellent functional group tolerance.
![Graphical abstract: Acid-catalyzed tandem reaction for the synthesis of pyridine derivatives via C [[double bond, length as m-dash]] C/C(sp3)–N bond cleavage of enones and primary amines](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7RA00780A&imageInfo.ImageIdentifier.Year=2017)
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![[double bond, length as m-dash]](https://www.rsc.org/images/entities/h2_char_e001.gif)
C/C(sp3)–N bond cleavage of enones and primary amines
