Issue 38, 2017, Issue in Progress

Shape-oriented photodynamic therapy of cuprous oxide (Cu2O) nanocrystals for cancer treatment

Abstract

We report a novel method used for the synthesis of cuprous oxide nanocrystals at room temperature by varying the concentration of the reducing agent and probed their photodynamic activity on HeLa cells. Three different shapes of cuprous oxide nanocrystals (NCs) were synthesized, including cubic, hexagonal and octahedral forms, and investigated for their photodynamic properties. Cuprous oxide generated reactive oxygen species (ROS) after irradiation with a green laser (λ = 532 nm). TEM, XRD, EDX, and FTIR were applied to characterize their shape factors and optical properties. Cubic, hexagonal and octahedral shapes of cuprous oxide nanocrystals were used for photodynamic therapy via incubation with HeLa cells and irradiation with a green laser. The octahedral NCs exhibit the highest photodynamic activity for killing HeLa cells, as evaluated using a trypan blue assay, and a high production of reactive oxygen species was observed.

Graphical abstract: Shape-oriented photodynamic therapy of cuprous oxide (Cu2O) nanocrystals for cancer treatment

Article information

Article type
Paper
Submitted
27 Dec 2016
Accepted
18 Mar 2017
First published
02 May 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 23607-23614

Shape-oriented photodynamic therapy of cuprous oxide (Cu2O) nanocrystals for cancer treatment

M. L. Bhaisare, M. S. Khan, S. Pandey, G. Gedda and H. Wu, RSC Adv., 2017, 7, 23607 DOI: 10.1039/C6RA28705K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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