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Issue 7, 2017
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1–42 C-terminus fragment derived peptides prevent the self-assembly of the parent peptide

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Abstract

In an attempt to design Aβ aggregation inhibitors to combat Alzheimer's disease, herein we report a full peptide scan performed on a pentapeptide fragment (Aβ38–42) derived from the C-terminus of Aβ1–42 peptide. More than thirty new peptides were synthesized and tested for their inhibition activity towards Aβ self-assembly. In the cell viability assay, when co-incubated with Aβ, three peptides were found to completely prevent the toxicity induced by Aβ aggregation. Most active pentapeptides were also studied by ThT fluorescence assay and the results were well correlated to the MTT study. The inhibition potential of a pentapeptide (15) was further confirmed by CD spectroscopy and transmission electron microscopy.

Graphical abstract: Aβ1–42 C-terminus fragment derived peptides prevent the self-assembly of the parent peptide

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Publication details

The article was received on 04 Nov 2016, accepted on 19 Dec 2016 and first published on 16 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA26295C
RSC Adv., 2017,7, 4167-4173
  • Open access: Creative Commons BY-NC license
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    1–42 C-terminus fragment derived peptides prevent the self-assembly of the parent peptide

    S. Bansal, I. K. Maurya, K. Shenmar, N. Yadav, C. K. Thota, V. Kumar, K. Tikoo, V. S. Chauhan and R. Jain, RSC Adv., 2017, 7, 4167
    DOI: 10.1039/C6RA26295C

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