Novel cytotoxic steroidal saponins from the roots of Liriope muscari (Decne.) L.H. Bailey

Abstract

Ten new steroidal saponins (1–10) and three known steroidal saponins (11–13) were isolated from a 70% EtOH extract of the roots of Liriope muscari (Decne.) L. H. Bailey. Their structures were determined by analyses of infrared, nuclear magnetic resonance and mass spectroscopic data. These compounds exhibited different levels of cytotoxic activity against MDA-MB-435, 95D, HepG2, HeLa, MCF-7 and A549 cell lines in an in vitro bioassay. The structure–activity relationship of these related compounds was also investigated.