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Issue 12, 2017
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Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

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Abstract

A 5-membered heterocyclic γ-amino acid scaffold possesses a wide range of bioactivities. Herein, we report a photoredox organocatalytic, highly selective α-amino C(sp3)–H bond functionalization to generate a reactive α-amino radical, which undergoes conjugate addition to Michael acceptors, providing an elegant intramolecular access to cyclic γ-amino acid analogues in satisfactory yields.

Graphical abstract: Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

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Article information


Submitted
27 Jul 2017
Accepted
05 Sep 2017
First published
06 Sep 2017

Org. Chem. Front., 2017,4, 2433-2436
Article type
Research Article

Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

J. Liu, J. Xie and C. Zhu, Org. Chem. Front., 2017, 4, 2433
DOI: 10.1039/C7QO00644F

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