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Issue 12, 2017
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Catalytic C–H amination at its limits: challenges and solutions

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Catalytic C–H amination reactions enable direct functionalization of non-activated C(sp3)–H bonds with high levels of regio-, chemo- and stereoselectivity. As a powerful tool to unlock the potential of inert C–H bonds, C–H amination chemistry has been applied to the preparation of synthetically challenging targets since major simplification of synthetic sequences are expected from this approach. Pushing C–H amination to its limits has led to a deeper understanding of the reaction mechanism and scope. In this review, we present a description of the specific challenges facing catalytic C–H amination in the synthesis of natural products and related compounds, as well as innovative tactics created to overcome them. By identifying and discussing the major insights gained and strategies designed, we hope that this review will stimulate further progress in C–H amination chemistry and beyond.

Graphical abstract: Catalytic C–H amination at its limits: challenges and solutions

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Publication details

The article was received on 03 Jul 2017, accepted on 04 Sep 2017 and first published on 12 Sep 2017

Article type: Review Article
DOI: 10.1039/C7QO00547D
Citation: Org. Chem. Front., 2017,4, 2500-2521

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    Catalytic C–H amination at its limits: challenges and solutions

    D. Hazelard, P. Nocquet and P. Compain, Org. Chem. Front., 2017, 4, 2500
    DOI: 10.1039/C7QO00547D

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