Jump to main content
Jump to site search

Issue 10, 2017
Previous Article Next Article

Gold(I)-catalyzed access to neomerane skeletons

Author affiliations


The gold(I) catalyzed cycloisomerization of an enynyl propargylic ester, featuring a 1,2-acyloxy migration/intramolecular cyclopropanation sequence, opens a straightforward access to the 5,7,3-tricyclic skeleton of neomerane sesquiterpenes. The first total synthesis of 5-epi-valeneomerin B in 12 steps with an overall yield of 5.3% from the readily available hex-5-en-2-one is reported.

Graphical abstract: Gold(i)-catalyzed access to neomerane skeletons

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 May 2017, accepted on 10 Jun 2017 and first published on 12 Jun 2017

Article type: Research Article
DOI: 10.1039/C7QO00360A
Org. Chem. Front., 2017,4, 1906-1916

  •   Request permissions

    Gold(I)-catalyzed access to neomerane skeletons

    C. Tugny, O. Khaled, E. Derat, J. Goddard, V. Mouriès-Mansuy and L. Fensterbank, Org. Chem. Front., 2017, 4, 1906
    DOI: 10.1039/C7QO00360A

Search articles by author