Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2017
Previous Article Next Article

Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles

Author affiliations

Abstract

A highly efficient method for the construction of pyrrolidinyl spirooxindoles with 3-isothiocyanato oxindoles and chalcones via a Michael/cyclization cascade reaction has been developed by using bifunctional cinchona-derived squaramide organocatalysts. A series of complex pyrrolidinyl spirooxindoles could be obtained in high yields (up to 99%) with excellent diastereo- and enantioselectivities (up to >99 : 1 dr, >99% ee) under mild conditions.

Graphical abstract: Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles

Back to tab navigation

Supplementary files

Article information


Submitted
25 Dec 2016
Accepted
15 Mar 2017
First published
16 Mar 2017

Org. Chem. Front., 2017,4, 1229-1238
Article type
Research Article

Squaramide-catalyzed asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles with chalcones for synthesis of pyrrolidinyl spirooxindoles

Y. Lin, L. Liu and D. Du, Org. Chem. Front., 2017, 4, 1229
DOI: 10.1039/C6QO00852F

Social activity

Search articles by author

Spotlight

Advertisements