Issue 1, 2017

Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

Abstract

A triethylamine-catalyzed domino reaction between phthalimidomalonate derivatives and activated alkynes has been developed. This catalytic protocol is applicable to the synthesis of structurally functionalized N-fused tricyclic 3-hydroxyisoindolin-1-ones.

Graphical abstract: Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

Supplementary files

Article information

Article type
Research Article
Submitted
14 Sep 2016
Accepted
22 Oct 2016
First published
25 Oct 2016

Org. Chem. Front., 2017,4, 119-123

Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

L. Zhang, B. Zhang, T. Jiang, T. Lu and Q. Zhou, Org. Chem. Front., 2017, 4, 119 DOI: 10.1039/C6QO00544F

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