Issue 1, 2017

Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

Abstract

In this work, gelatin was crosslinked with oxidized alginate in the presence of borax yielding a hybrid biohydrogel system with the ability to self-repair upon mechanical damage. A judicious balance between concentration, stoichiometric ratio of the two biopolymers and gelatin source was found necessary to achieve optimal self-healing properties of these biohydrogels. The pH was found to have a major influence on the reconstruction of the damaged hydrogel interface, confirming that the dynamic Schiff base linkages between the amine groups of gelatin and the aldehyde groups of oxidized alginate play a fundamental role on the healing process of the hybrid gels.

Graphical abstract: Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

Article information

Article type
Research Article
Submitted
25 May 2016
Accepted
15 Jun 2016
First published
29 Jul 2016
This article is Open Access
Creative Commons BY license

Mater. Chem. Front., 2017,1, 73-79

Self-healing alginate–gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters

A. Pettignano, M. Häring, L. Bernardi, N. Tanchoux, F. Quignard and D. Díaz Díaz, Mater. Chem. Front., 2017, 1, 73 DOI: 10.1039/C6QM00066E

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