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Issue 7, 2017
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In situ luminescence analysis: a new light on monitoring calcium phosphate phase transitions

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Abstract

In this work, in situ luminescence analysis was applied for the first time for monitoring the phase transitions of calcium phosphate (CaP) and confirmed by synchrotron in situ X-ray diffraction in addition to in situ infrared spectroscopy, with simultaneous measurements of pH and ion conductivity. Applying doped Ce3+ and Eu3+ as local coordination sensors, the high sensitivity of their emission spectra upon the changes in the coordination sphere of the doped cation sites enabled to detect the formation of amorphous calcium phosphate (ACP) and Ca5(PO4)3OH, besides their subsequent transitions to CaHPO4·2H2O and Ca8H2(PO4)6·5H2O under real reaction conditions. Calcium phosphates are widely present in mammals and understanding their phase transitions is important to comprehend the conversion between healthy and diseased tissues. In situ luminescence measurements are advantageous for allowing monitoring these phase transitions in a fast and sensitive fashion also in conventional laboratories, independent of synchrotron radiation.

Graphical abstract: In situ luminescence analysis: a new light on monitoring calcium phosphate phase transitions

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Supplementary files

Article information


Submitted
29 Mar 2017
Accepted
04 May 2017
First published
05 May 2017

This article is Open Access

Inorg. Chem. Front., 2017,4, 1157-1165
Article type
Research Article

In situ luminescence analysis: a new light on monitoring calcium phosphate phase transitions

H. Terraschke, M. Rothe, A.-M. Tsirigoni, P. Lindenberg, L. Ruiz Arana, N. Heidenreich, F. Bertram and M. Etter, Inorg. Chem. Front., 2017, 4, 1157
DOI: 10.1039/C7QI00172J

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