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Issue 31, 2017
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Bio-inks for 3D bioprinting: recent advances and future prospects

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In the last decade, interest in the field of three-dimensional (3D) bioprinting has increased enormously. 3D bioprinting combines the fields of developmental biology, stem cells, and computer and materials science to create complex bio-hybrid structures for various applications. It is able to precisely place different cell types, biomaterials and biomolecules together in a predefined position to generate printed composite architectures. In the field of tissue engineering, 3D bioprinting has allowed the study of tissues and organs on a new level. In clinical applications, new models have been generated to study disease pathogenesis. One of the most important components of 3D bio-printing is the bio-ink, which is a mixture of cells, biomaterials and bioactive molecules that creates the printed article. This review describes all the currently used bio-printing inks, including polymeric hydrogels, polymer bead microcarriers, cell aggregates and extracellular matrix proteins. Amongst the polymeric components in bio-inks are: natural polymers including gelatin, hyaluronic acid, silk proteins and elastin; and synthetic polymers including amphiphilic block copolymers, PEG, poly(PNIPAAM) and polyphosphazenes. Furthermore, photocrosslinkable and thermoresponsive materials are described. To provide readers with an understanding of the context, the review also contains an overview of current bio-printing techniques and finishes with a summary of bio-printing applications.

Graphical abstract: Bio-inks for 3D bioprinting: recent advances and future prospects

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Article information

18 May 2017
07 Jul 2017
First published
10 Jul 2017

Polym. Chem., 2017,8, 4451-4471
Article type
Review Article

Bio-inks for 3D bioprinting: recent advances and future prospects

I. Donderwinkel, J. C. M. van Hest and N. R. Cameron, Polym. Chem., 2017, 8, 4451
DOI: 10.1039/C7PY00826K

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