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Issue 34, 2017
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Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

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Abstract

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

Graphical abstract: Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

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Supplementary files

Article information


Submitted
02 Feb 2017
Accepted
12 Feb 2017
First published
22 Feb 2017

Polym. Chem., 2017,8, 4983-4987
Article type
Communication

Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

J. A. Alfurhood, H. Sun, C. P. Kabb, B. S. Tucker, J. H. Matthews, H. Luesch and B. S. Sumerlin, Polym. Chem., 2017, 8, 4983
DOI: 10.1039/C7PY00196G

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