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Issue 8, 2017

Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

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Abstract

Star-shaped poly(ethylene glycol)-N-hydroxysuccinimide (star-PEG-NHS) has shown great promise in a variety of biomedical applications owing to its non-toxicity, innate non-immunogenic properties and versatile, multifunctional end groups. However, its complex and sophisticated synthetic methods, as well as high costs, have significantly impeded its wide application. Here, we report the design and synthesis of a hyperbranched PEG-based polymer with multiple NHS functional groups (>12). The hyperbranched PEG-based multi-NHS polymer can react easily with a protein (bovine serum albumin, BSA) to form a PEG-protein hydrogel that displays great potential for biomedical applications.

Graphical abstract: Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

Supplementary files

Article information


Submitted
02 Oct 2016
Accepted
22 Dec 2016
First published
04 Jan 2017

Polym. Chem., 2017,8, 1283-1287
Article type
Communication

Hyperbranched PEG-based multi-NHS polymer and bioconjugation with BSA

S. A, Q. Xu, D. Zhou, Y. Gao, J. M. Vasquez, U. Greiser, W. Wang, W. Liu and W. Wang, Polym. Chem., 2017, 8, 1283 DOI: 10.1039/C6PY01719C

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