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Issue 48, 2017
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Nitrilium ions – synthesis and applications

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Nitrilium ions have been well-established in organic chemistry for many decades, but recent developments show them to be far more versatile than hitherto recognized. They are known as stable salts, can be generated in situ, or are present as transient intermediates. We provide a succinct, but comprehensive review on the synthesis, stability, and reactivity of nitrilium ions as synthons for imines, their use in the synthesis of a large spectrum of heterocycles, and their reactions with transition metal complexes. By offering this overview, we aim for a renewed focus on readily accessible and simple to use nitrilium ions as valuable reagents for the synthesis of organic compounds.

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Article information

12 Oct 2017
16 Nov 2017
First published
16 Nov 2017

Org. Biomol. Chem., 2017,15, 10134-10144
Article type
Review Article

Nitrilium ions – synthesis and applications

T. van Dijk, J. Chris Slootweg and K. Lammertsma, Org. Biomol. Chem., 2017, 15, 10134
DOI: 10.1039/C7OB02533E

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