Issue 1, 2018

Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

Abstract

A palladium mediated C–H aziridination reaction of 3,3,5,5-substituted-piperazin-2-ones has been developed using phenyliodonium diacetate (PIDA) and succinic acid to give synthetically useful bicyclic aziridines, in moderate to good yields. Succinic acid was found to be key for selectively promoting C–N bond formation (aziridination) and suppressing competitive acetoxylation. Analysis of the reaction kinetics revealed the role of succinic acid in promoting an equilibrium between monomeric and dimeric palladium species in the rate determining step of the reaction. The aziridines can be ring-opened by nucleophiles under Lewis or Brønsted acidic conditions to give formal C–H functionalized products. The reaction conditions can be further manipulated to produce acetoxylated, diacetoxylated and even triacetoxylated materials through the use of acetic acid and increased oxidant stoichiometry.

Graphical abstract: Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2017
Accepted
04 Dec 2017
First published
04 Dec 2017

Org. Biomol. Chem., 2018,16, 53-56

Pd-Catalyzed C–H aziridination of 3,3,5,5-tetrasubstituted piperazin-2-ones

T. A. Alanine, S. Stokes, C. A. Roberts and James. S. Scott, Org. Biomol. Chem., 2018, 16, 53 DOI: 10.1039/C7OB02486J

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