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Issue 46, 2017
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Cooperative bimetallic catalysis in asymmetric allylic substitution

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Synergistic catalysis is gaining increasing attention due to its advantages over traditional catalytic methodologies, such as improved catalytic activity, broader substrate scope, increased selectivity and lower cost. Methodologies involving the synergistic combination of metal catalysts and organocatalysts have been intensively studied. Given the clear benefits of bimetallic catalyst systems consisting of two distinct metal catalysts, cooperative bimetallic catalysis has proved to be successful for a number of difficult asymmetric transformations. This review highlights the recent advances in bimetallic systems for catalytic asymmetric allylic substitution reactions. Strategies using a chiral metal catalyst and the cooperative effect of a second achiral metal catalyst for asymmetric transformations are discussed. Additionally, several challenging asymmetric reactions realized by employing two different chiral metal catalysts in a synergistic manner are also covered.

Graphical abstract: Cooperative bimetallic catalysis in asymmetric allylic substitution

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Publication details

The article was received on 06 Oct 2017, accepted on 01 Nov 2017 and first published on 09 Nov 2017

Article type: Review Article
DOI: 10.1039/C7OB02476B
Citation: Org. Biomol. Chem., 2017,15, 9747-9759
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    Cooperative bimetallic catalysis in asymmetric allylic substitution

    J. Fu, X. Huo, B. Li and W. Zhang, Org. Biomol. Chem., 2017, 15, 9747
    DOI: 10.1039/C7OB02476B

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