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Issue 42, 2017
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A cryptophane-based “turn-on” 129Xe NMR biosensor for monitoring calmodulin

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Abstract

We present the first cryptophane-based “turn-on” 129Xe NMR biosensor, employing a peptide-functionalized cryptophane to monitor the activation of calmodulin (CaM) protein in solution. In the absence of CaM binding, interaction between the peptide and cryptophane completely suppresses the hyperpolarized 129Xe-cryptophane NMR signal. Biosensor binding to Ca2+-activated CaM produces the expected 129Xe-cryptophane NMR signal.

Graphical abstract: A cryptophane-based “turn-on” 129Xe NMR biosensor for monitoring calmodulin

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Publication details

The article was received on 24 Sep 2017, accepted on 16 Oct 2017 and first published on 16 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02391J
Org. Biomol. Chem., 2017,15, 8883-8887

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    A cryptophane-based “turn-on” 129Xe NMR biosensor for monitoring calmodulin

    B. A. Riggle, M. L. Greenberg, Y. Wang, R. F. Wissner, S. D. Zemerov, E. J. Petersson and I. J. Dmochowski, Org. Biomol. Chem., 2017, 15, 8883
    DOI: 10.1039/C7OB02391J

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