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Issue 44, 2017
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The iso-Nazarov reaction

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The construction of five-membered rings is essential in organic chemistry. In this context, pentannulation reactions that provide a straightforward access to cyclopentenones are of particular interest, as these structures are not only embedded in important molecules such as some prostaglandins, but also serve as versatile building blocks in organic synthesis. This review documents the acid-promoted cycloisomerization of conjugated dienals and linearly-conjugated dienones for the construction of cyclopentenones, a transformation that has been largely eclipsed by the well-known Nazarov reaction, i.e. the acid-promoted cycloisomerization of cross-conjugated ketones.

Graphical abstract: The iso-Nazarov reaction

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Publication details

The article was received on 04 Sep 2017, accepted on 20 Oct 2017 and first published on 23 Oct 2017

Article type: Review Article
DOI: 10.1039/C7OB02220D
Citation: Org. Biomol. Chem., 2017,15, 9255-9274
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    The iso-Nazarov reaction

    M. J. Riveira, L. A. Marsili and M. P. Mischne, Org. Biomol. Chem., 2017, 15, 9255
    DOI: 10.1039/C7OB02220D

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