Jump to main content
Jump to site search

Issue 38, 2017
Previous Article Next Article

One-pot synthesis of 2,3-difunctionalized indoles via Rh(iii)-catalyzed carbenoid insertion C–H activation/cyclization

Author affiliations

Abstract

Reported herein is the first Rh(III)-catalyzed carbenoid insertion C–H activation/cyclization of N-arylureas and α-diazo β-keto esters. The redox-neutral reaction has the following features: good to excellent yields, broad substrate/functional group tolerance, exclusive regioselectivity, and no need for additional oxidants or additives, which render this methodology as a more efficient and versatile alternative to the existing methods for the synthesis of 2,3-difunctionalized indoles.

Graphical abstract: One-pot synthesis of 2,3-difunctionalized indoles via Rh(iii)-catalyzed carbenoid insertion C–H activation/cyclization

Back to tab navigation

Supplementary files

Article information


Submitted
09 Aug 2017
Accepted
05 Sep 2017
First published
05 Sep 2017

Org. Biomol. Chem., 2017,15, 8054-8058
Article type
Paper

One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C–H activation/cyclization

H. Lv, J. Shi, B. Wu, Y. Guo, J. Huang and W. Yi, Org. Biomol. Chem., 2017, 15, 8054
DOI: 10.1039/C7OB01977G

Social activity

Search articles by author

Spotlight

Advertisements