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A desulfitative arylation of 2-aryloxazole-4-carboxylate with sodium arylsulfinates under an oxygen (O2) atmosphere to afford 2,5-diarylated oxazole-4-carboxylates is described. This transformation provides a novel approach for the utilization of sodium arylsulfinates as the aryl source and O2 as the sole oxidant.

Graphical abstract: Pd-catalyzed desulfitative arylation for the synthesis of 2,5-diarylated oxazole-4-carboxylates using dioxygen as the terminal oxidant

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