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Abstract | Cited by

Direct trifluoroacetylation of indoles with ethyl trifluoropyruvate as a trifluoroacetylating reagent has been developed. This novel protocol provides an attractive route for the preparation of 3-trifluoroacetylindole derivatives, due to its operational simplicity and practicability as well as mild reaction conditions.

Graphical abstract: Copper-mediated trifluoroacetylation of indoles with ethyl trifluoropyruvate

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