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Issue 35, 2017
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Amphiphilic carbosilane dendrons as a novel synthetic platform toward micelle formation

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Abstract

A novel family of amphiphilic ionic carbosilane dendrons containing fatty acids at the focal point were synthesized and characterized. They spontaneously self-assembled in aqueous solution into micelles both in the absence and presence of salt, as confirmed by surface tension, conductivity, and DLS measurements. Dendron based micelles have spherical shapes and increase in size on decreasing dendron generation. These dendritic micelles have been demonstrated to be able to form complexes with therapeutic macromolecules such as siRNA and show a high loading capacity for drugs such as procaine, suggesting their potential use as nanocarriers for therapeutics.

Graphical abstract: Amphiphilic carbosilane dendrons as a novel synthetic platform toward micelle formation

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Publication details

The article was received on 31 May 2017, accepted on 07 Aug 2017 and first published on 22 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01331K
Org. Biomol. Chem., 2017,15, 7352-7364
  • Open access: Creative Commons BY-NC license
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    Amphiphilic carbosilane dendrons as a novel synthetic platform toward micelle formation

    C. E. Gutierrez-Ulloa, M. Yu. Buyanova, E. K. Apartsin, A. G. Venyaminova, F. J. de la Mata, M. Valiente and R. Gómez, Org. Biomol. Chem., 2017, 15, 7352
    DOI: 10.1039/C7OB01331K

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