Issue 26, 2017

Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

Abstract

A ruthenium pincer catalyst has been shown to be highly efficient for the hydrogenation of a wide range of α-ketimino esters derived from α-keto esters and chiral 2-methylpropyl-2-sulfinamide, affording chiral aryl glycine derivatives with high yields and diasteroselectivities (20 examples, dr values up to 99 : 1).

Graphical abstract: Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

Supplementary files

Article information

Article type
Communication
Submitted
31 May 2017
Accepted
15 Jun 2017
First published
15 Jun 2017

Org. Biomol. Chem., 2017,15, 5468-5471

Ru-Catalyzed highly diastereoselective hydrogenation of N-tert-butylsulfinyl ketimines for the synthesis of aryl glycine derivatives

Q. Wei, F. Zhang, X. Zhao, C. Wang, J. Xiao and W. Tang, Org. Biomol. Chem., 2017, 15, 5468 DOI: 10.1039/C7OB01329A

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