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Issue 26, 2017
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Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels–Alder and ene-reactions

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Abstract

Thermic dimerization of methyl 1,3-cyclohexadiene 2-carboxylate gave original 3D-shape compounds by Diels–Alder cycloaddition and original [6 + 4]-ene reaction. Further selective modifications on an endo [4 + 2] cycloadduct via a diversity oriented synthesis (DOS) strategy quickly led to the preparation of a small library of original 3D scaffolds, providing access to a larger and unexplored chemical space for drug discovery processes.

Graphical abstract: Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels–Alder and ene-reactions

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Supplementary files

Article information


Submitted
19 May 2017
Accepted
08 Jun 2017
First published
08 Jun 2017

Org. Biomol. Chem., 2017,15, 5585-5592
Article type
Paper

Fast & easy preparation of 3D scaffolds from methyl benzoate by a diversity oriented synthesis strategy based on Diels–Alder and ene-reactions

D. Brossard, P. Retailleau, V. Dumontet, P. Breton, S. Desrat and F. Roussi, Org. Biomol. Chem., 2017, 15, 5585
DOI: 10.1039/C7OB01236E

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