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Issue 27, 2017
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Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation

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Abstract

A diversity-oriented access to isoxazolino and isoxazolo benzazepines is elaborated via a post-Ugi heteroannulation involving intramolecular 1,3-dipolar cycloaddition reaction of nitrile oxides with alkenes and alkynes. This sequence offers an interesting multicomponent entry to a library of isoxazolino and isoxazolo benzazepines under mild reaction conditions in good to excellent yields.

Graphical abstract: Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation

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Article information


Submitted
10 May 2017
Accepted
20 Jun 2017
First published
20 Jun 2017

Org. Biomol. Chem., 2017,15, 5737-5742
Article type
Paper

Direct access to isoxazolino and isoxazolo benzazepines from 2-((hydroxyimino)methyl)benzoic acid via a post-Ugi heteroannulation

S. Balalaie, M. Shamakli, A. Nikbakht, N. S. Alavijeh, F. Rominger, S. Rostamizadeh and H. R. Bijanzadeh, Org. Biomol. Chem., 2017, 15, 5737
DOI: 10.1039/C7OB01142C

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