Henry P. Pepper, Hiu C. Lam and Jonathan H. George
Org. Biomol. Chem., 2017,15, 4811-4815
DOI:
10.1039/C7OB00868F,
Paper
The synthesis of verrubenzospirolactone from its proposed biosynthetic precursor, capillobenzopyranol, has been shown to be chemically feasible via a simple reaction sequence. The key steps are a chemoselective furan oxidation mediated by NaClO2, a stereoselective dehydration of a γ-methoxybutenolide, and an intramolecular Diels–Alder reaction.
