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Issue 23, 2017
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Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

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Abstract

The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero)aryl-1H-indazoles, is documented for the first time. The product 1H-indazoles can be transformed subsequently in a one-pot procedure into 1,3-di(hetero)aryl-1H-indazoles via copper-catalyzed N-arylation with (hetero)aryl bromides.

Graphical abstract: Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

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Publication details

The article was received on 04 Apr 2017, accepted on 19 May 2017 and first published on 23 May 2017


Article type: Paper
DOI: 10.1039/C7OB00841D
Org. Biomol. Chem., 2017,15, 5062-5069

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    Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

    C. Wiethan, C. M. Lavoie, A. Borzenko, J. S. K. Clark, H. G. Bonacorso and M. Stradiotto, Org. Biomol. Chem., 2017, 15, 5062
    DOI: 10.1039/C7OB00841D

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