Jump to main content
Jump to site search

Issue 21, 2017
Previous Article Next Article

Regioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines

Author affiliations

Abstract

A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C–H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.

Graphical abstract: Regioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines

Back to tab navigation

Supplementary files

Article information


Submitted
18 Mar 2017
Accepted
04 May 2017
First published
05 May 2017

Org. Biomol. Chem., 2017,15, 4686-4696
Article type
Paper

Regioselective 6-endo-dig iodocyclization: an accessible approach for iodo-benzo[a]phenazines

S. Kumar, M. Mujahid and A. K. Verma, Org. Biomol. Chem., 2017, 15, 4686
DOI: 10.1039/C7OB00671C

Social activity

Search articles by author

Spotlight

Advertisements