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Issue 18, 2017
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Square sugars: challenges and synthetic strategies

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Square sugars (4-membered ring carbohydrate mimetics) are at the intersection of several important topics concerning the recent emergence, in medicinal chemistry, of glycomimetic drugs and small ring systems. Monosaccharide mimetics containing oxetane, azetidine, thiethane or cyclobutane rings present a number of synthetic challenges that are a powerful driving force for innovation in organic synthesis. In addition to the inherent issues associated with 4-membered rings, the high density of functional groups and asymmetric centres found in glycomimetics further complicates the matter and requires efficient stereoselective methodologies. The purpose of this review is to present an overview of the elegant strategies that have been developed to synthesize the different types of square sugars.

Graphical abstract: Square sugars: challenges and synthetic strategies

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Publication details

The article was received on 16 Feb 2017, accepted on 15 Mar 2017 and first published on 16 Mar 2017

Article type: Review Article
DOI: 10.1039/C7OB00386B
Citation: Org. Biomol. Chem., 2017,15, 3806-3827

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    Square sugars: challenges and synthetic strategies

    D. Hazelard and P. Compain, Org. Biomol. Chem., 2017, 15, 3806
    DOI: 10.1039/C7OB00386B

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