Issue 18, 2017

Square sugars: challenges and synthetic strategies

Abstract

Square sugars (4-membered ring carbohydrate mimetics) are at the intersection of several important topics concerning the recent emergence, in medicinal chemistry, of glycomimetic drugs and small ring systems. Monosaccharide mimetics containing oxetane, azetidine, thiethane or cyclobutane rings present a number of synthetic challenges that are a powerful driving force for innovation in organic synthesis. In addition to the inherent issues associated with 4-membered rings, the high density of functional groups and asymmetric centres found in glycomimetics further complicates the matter and requires efficient stereoselective methodologies. The purpose of this review is to present an overview of the elegant strategies that have been developed to synthesize the different types of square sugars.

Graphical abstract: Square sugars: challenges and synthetic strategies

Article information

Article type
Review Article
Submitted
16 Feb 2017
Accepted
15 Mar 2017
First published
16 Mar 2017

Org. Biomol. Chem., 2017,15, 3806-3827

Square sugars: challenges and synthetic strategies

D. Hazelard and P. Compain, Org. Biomol. Chem., 2017, 15, 3806 DOI: 10.1039/C7OB00386B

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