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Issue 11, 2017
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Isoafricanol synthase from Streptomyces malaysiensis

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Genome sequencing of Streptomyces malaysiensis DSM 4137 revealed the presence of four terpene cyclase genes, one of which was characterised as (+)-isoafricanol synthase. Its cyclisation mechanism was extensively studied using isotopically labelled precursors. Several enzymes with high homology that likely also function as (+)-isoafricanol synthases are encoded in a number of other genome sequenced streptomycetes.

Graphical abstract: Isoafricanol synthase from Streptomyces malaysiensis

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Article information

30 Jan 2017
20 Feb 2017
First published
01 Mar 2017

Org. Biomol. Chem., 2017,15, 2353-2358
Article type

Isoafricanol synthase from Streptomyces malaysiensis

P. Rabe, M. Samborskyy, P. F. Leadlay and J. S. Dickschat, Org. Biomol. Chem., 2017, 15, 2353
DOI: 10.1039/C7OB00234C

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