Divergent response of homologous ATP sites to stereospecific ligand fluorination for selectivity enhancement

Abstract

Acquiring a divergent response from homologous protein domains is essential for selective ligand–protein interactions. Stereospecific fluorination of (−)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.