Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds†
Liang
Wang, 
ab
Xuehu
Li,
a
Hua
Tao,
c
Xiang
Zhou,
a
Xihong
Lu,
a
Wenyue
Du,
a
Tingting
Jiang,
ab
Zhijun
Xin
*a
and
Jianping
Liang
*a
ab
Xuehu
Li,
a
Hua
Tao,
c
Xiang
Zhou,
a
Xihong
Lu,
a
Wenyue
Du,
a
Tingting
Jiang,
ab
Zhijun
Xin
*a
and
Jianping
Liang
*a
Abstract
A highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds using a novel palladium-catalyzed tandem cyclization reaction is explored. During the reaction process, C–O, C–C and C–O bonds are sequentially formed in one pot via decarboxylative allenylpalladium formation, nucleophilic attack, arylpalladium addition and intramolecular nucleophilic attack.
![Graphical abstract: Palladium-catalyzed intermolecular tandem cyclization reaction: a highly regioselective synthesis of functionalized 3H-spiro[isobenzofuran-1,3′-isochroman] scaffolds](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6OB02802K&imageInfo.ImageIdentifier.Year=2017)
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